                         SEQUENCE LISTING



<110>  Emtage, Peter 



<120>  METHODS OF THERAPY AND DIAGNOSIS USING TARGETING OF CELLS THAT EXPRESS 
       A HUMAN TRANSPORTER-LIKE PROTEIN



<130>  NUVO-03CP/PCT



<140>  Not Yet Assigned

<141>  2004-04-20



<150>  10/420,268 

<151>  2003-04-21



<160>  5     



<170>  PatentIn version 3.1



<210>  1

<211>  7347

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (273)..(3806)

<223>  



<400>  1
agcggggtca ataatgaagg tggctgcggc gcggcggcag gctcagctgc gccgggcggg     60

ggcggcgctg tggtgccgcg cctgtaggac tcggggccga cgccgcggga tgtgggactg    120

cggcgcggtg gagtgaggct agtggctggc ggcggcggta agcggaactt cggcccgagg    180

ggctcgcccg ctcccgcctc tgtcttgtcg tgcctccacc tgcagccccg cggccccgcg    240

ccccgcggga cccggacggc gacgacgggg ga atg tgg cgc tgg atc cgg cag      293
                                    Met Trp Arg Trp Ile Arg Gln         
                                    1               5                   

cag ctg ggt ttt gac cca cca cat cag agt gac aca aga acc atc tac      341
Gln Leu Gly Phe Asp Pro Pro His Gln Ser Asp Thr Arg Thr Ile Tyr         
        10                  15                  20                      

gta gcc aac agg ttt cct cag aat ggc ctt tac aca cct cag aaa ttt      389
Val Ala Asn Arg Phe Pro Gln Asn Gly Leu Tyr Thr Pro Gln Lys Phe         
    25                  30                  35                          

ata gat aac agg atc att tca tct aag tac act gtg tgg aat ttt gtt      437
Ile Asp Asn Arg Ile Ile Ser Ser Lys Tyr Thr Val Trp Asn Phe Val         
40                  45                  50                  55          

cca aaa aat tta ttt gaa cag ttc aga aga gtg gca aac ttt tat ttt      485
Pro Lys Asn Leu Phe Glu Gln Phe Arg Arg Val Ala Asn Phe Tyr Phe         
                60                  65                  70              

ctt att ata ttt ttg gtt cag ctt atg att gat aca cct acc agt cca      533
Leu Ile Ile Phe Leu Val Gln Leu Met Ile Asp Thr Pro Thr Ser Pro         
            75                  80                  85                  

gtt acc agt gga ctt cca tta ttc ttt gtg ata aca gta act gcc ata      581
Val Thr Ser Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile         
        90                  95                  100                     

aag cag gga tat gaa gat tgg tta cgg cat aac tca gat aat gaa gta      629
Lys Gln Gly Tyr Glu Asp Trp Leu Arg His Asn Ser Asp Asn Glu Val         
    105                 110                 115                         

aat gga gct cct gtt tat gtt gtt cga agt ggt ggc ctt gta aaa act      677
Asn Gly Ala Pro Val Tyr Val Val Arg Ser Gly Gly Leu Val Lys Thr         
120                 125                 130                 135         

aga tca aaa aac att cgg gtg ggt gat att gtt cga ata gcc aaa gat      725
Arg Ser Lys Asn Ile Arg Val Gly Asp Ile Val Arg Ile Ala Lys Asp         
                140                 145                 150             

gaa att ttt cct gca gac ttg gtg ctt ctg tcc tca gat cga ctg gat      773
Glu Ile Phe Pro Ala Asp Leu Val Leu Leu Ser Ser Asp Arg Leu Asp         
            155                 160                 165                 

ggt tcc tgt cac gtt aca act gct agt ttg gac gga gaa act aac ctg      821
Gly Ser Cys His Val Thr Thr Ala Ser Leu Asp Gly Glu Thr Asn Leu         
        170                 175                 180                     

aag aca cat gtg gca gtt cca gaa aca gca tta tta caa aca gtt gcc      869
Lys Thr His Val Ala Val Pro Glu Thr Ala Leu Leu Gln Thr Val Ala         
    185                 190                 195                         

aat ttg gac act cta gta gct gta ata gaa tgc cag caa cca gaa gca      917
Asn Leu Asp Thr Leu Val Ala Val Ile Glu Cys Gln Gln Pro Glu Ala         
200                 205                 210                 215         

gac tta tac aga ttc atg gga cga atg atc ata acc caa caa atg gaa      965
Asp Leu Tyr Arg Phe Met Gly Arg Met Ile Ile Thr Gln Gln Met Glu         
                220                 225                 230             

gaa att gta aga cct ctg ggg ccg gag agt ctc ctg ctt cgt gga gcc     1013
Glu Ile Val Arg Pro Leu Gly Pro Glu Ser Leu Leu Leu Arg Gly Ala         
            235                 240                 245                 

aga tta aaa aac aca aaa gaa att ttt ggt gtt gcg gta tac act gga     1061
Arg Leu Lys Asn Thr Lys Glu Ile Phe Gly Val Ala Val Tyr Thr Gly         
        250                 255                 260                     

atg gaa act aag atg gca tta aat tac aag agc aaa tca cag aaa cga     1109
Met Glu Thr Lys Met Ala Leu Asn Tyr Lys Ser Lys Ser Gln Lys Arg         
    265                 270                 275                         

tct gca gta caa aag tca atg aat aca ttt ttg ata att tat cta gta     1157
Ser Ala Val Gln Lys Ser Met Asn Thr Phe Leu Ile Ile Tyr Leu Val         
280                 285                 290                 295         

att ctt ata tct gaa gct gtc atc agc act atc ttg aag tat aca tgg     1205
Ile Leu Ile Ser Glu Ala Val Ile Ser Thr Ile Leu Lys Tyr Thr Trp         
                300                 305                 310             

caa gct gaa gaa aaa tgg gat gaa cct tgg tat aac caa aaa aca gaa     1253
Gln Ala Glu Glu Lys Trp Asp Glu Pro Trp Tyr Asn Gln Lys Thr Glu         
            315                 320                 325                 

cat caa aga aat agc agt aag att ctg aga ttt att tca gac ttc ctt     1301
His Gln Arg Asn Ser Ser Lys Ile Leu Arg Phe Ile Ser Asp Phe Leu         
        330                 335                 340                     

gct ttt ttg gtt ctc tac aat ttc atc att cca att tca tta tat gtg     1349
Ala Phe Leu Val Leu Tyr Asn Phe Ile Ile Pro Ile Ser Leu Tyr Val         
    345                 350                 355                         

aca gtc gaa atg cag aaa ttt ctt gga tca ttt ttt att ggc tgg gat     1397
Thr Val Glu Met Gln Lys Phe Leu Gly Ser Phe Phe Ile Gly Trp Asp         
360                 365                 370                 375         

ctt gat ctg tat cat gaa gaa tca gat cag aaa gct caa gtc aat act     1445
Leu Asp Leu Tyr His Glu Glu Ser Asp Gln Lys Ala Gln Val Asn Thr         
                380                 385                 390             

tcc gat ctg aat gaa gag ctt gga cag gta gag tac gtg ttt aca gat     1493
Ser Asp Leu Asn Glu Glu Leu Gly Gln Val Glu Tyr Val Phe Thr Asp         
            395                 400                 405                 

aaa act ggt aca ctg aca gaa aat gag atg cag ttt cgg gaa tgt tca     1541
Lys Thr Gly Thr Leu Thr Glu Asn Glu Met Gln Phe Arg Glu Cys Ser         
        410                 415                 420                     

att aat ggc atg aaa tac caa gaa att aat ggt aga ctt gta ccc gaa     1589
Ile Asn Gly Met Lys Tyr Gln Glu Ile Asn Gly Arg Leu Val Pro Glu         
    425                 430                 435                         

gga cca aca cca gac tct tca gaa gga aac tta tct tat ctt agt agt     1637
Gly Pro Thr Pro Asp Ser Ser Glu Gly Asn Leu Ser Tyr Leu Ser Ser         
440                 445                 450                 455         

tta tcc cat ctt aac aac tta tcc cat ctt aca acc agt tcc tct ttc     1685
Leu Ser His Leu Asn Asn Leu Ser His Leu Thr Thr Ser Ser Ser Phe         
                460                 465                 470             

aga acc agt cct gaa aat gaa act gaa cta att aaa gaa cat gat ctc     1733
Arg Thr Ser Pro Glu Asn Glu Thr Glu Leu Ile Lys Glu His Asp Leu         
            475                 480                 485                 

ttc ttt aaa gca gtc agt ctc tgt cac act gta cag att agc aat gtt     1781
Phe Phe Lys Ala Val Ser Leu Cys His Thr Val Gln Ile Ser Asn Val         
        490                 495                 500                     

caa act gac tgc act ggt gat ggt ccc tgg caa tcc aac ctg gca cca     1829
Gln Thr Asp Cys Thr Gly Asp Gly Pro Trp Gln Ser Asn Leu Ala Pro         
    505                 510                 515                         

tcg cag ttg gag tac tat gca tct tca cca gat gaa aag gct cta gta     1877
Ser Gln Leu Glu Tyr Tyr Ala Ser Ser Pro Asp Glu Lys Ala Leu Val         
520                 525                 530                 535         

gaa gct gct gca agg att ggt att gtg ttt att ggc aat tct gaa gaa     1925
Glu Ala Ala Ala Arg Ile Gly Ile Val Phe Ile Gly Asn Ser Glu Glu         
                540                 545                 550             

act atg gag gtt aaa act ctt gga aaa ctg gaa cgg tac aaa ctg ctt     1973
Thr Met Glu Val Lys Thr Leu Gly Lys Leu Glu Arg Tyr Lys Leu Leu         
            555                 560                 565                 

cat att ctg gaa ttt gat tca gat cgt agg aga atg agt gta att gtt     2021
His Ile Leu Glu Phe Asp Ser Asp Arg Arg Arg Met Ser Val Ile Val         
        570                 575                 580                     

cag gca cct tca ggt gag aag tta tta ttt gct aaa gga gct gag tca     2069
Gln Ala Pro Ser Gly Glu Lys Leu Leu Phe Ala Lys Gly Ala Glu Ser         
    585                 590                 595                         

tca att ctc cct aaa tgt ata ggt gga gaa ata gaa aaa acc aga att     2117
Ser Ile Leu Pro Lys Cys Ile Gly Gly Glu Ile Glu Lys Thr Arg Ile         
600                 605                 610                 615         

cat gta gat gaa ttt gct ttg aaa ggg cta aga act ctg tgt ata gca     2165
His Val Asp Glu Phe Ala Leu Lys Gly Leu Arg Thr Leu Cys Ile Ala         
                620                 625                 630             

tat aga aaa ttt aca tca aaa gag tat gag gaa ata gat aaa cgc ata     2213
Tyr Arg Lys Phe Thr Ser Lys Glu Tyr Glu Glu Ile Asp Lys Arg Ile         
            635                 640                 645                 

ttt gaa gcc agg act gcc ttg cag cag cgg gaa gag aaa ttg gca gct     2261
Phe Glu Ala Arg Thr Ala Leu Gln Gln Arg Glu Glu Lys Leu Ala Ala         
        650                 655                 660                     

gtt ttc cag ttc ata gag aaa gac ctg ata tta ctt gga gcc aca gca     2309
Val Phe Gln Phe Ile Glu Lys Asp Leu Ile Leu Leu Gly Ala Thr Ala         
    665                 670                 675                         

gta gaa gac aga cta caa gat aaa gtt cga gaa act att gaa gca ttg     2357
Val Glu Asp Arg Leu Gln Asp Lys Val Arg Glu Thr Ile Glu Ala Leu         
680                 685                 690                 695         

aga atg gct ggt atc aaa gta tgg gta ctt act ggg gat aaa cat gaa     2405
Arg Met Ala Gly Ile Lys Val Trp Val Leu Thr Gly Asp Lys His Glu         
                700                 705                 710             

aca gct gtt agt gtg agt tta tca tgt ggc cat ttt cat aga acc atg     2453
Thr Ala Val Ser Val Ser Leu Ser Cys Gly His Phe His Arg Thr Met         
            715                 720                 725                 

aac atc ctt gaa ctt ata aac cag aaa tca gac agc gag tgt gct gaa     2501
Asn Ile Leu Glu Leu Ile Asn Gln Lys Ser Asp Ser Glu Cys Ala Glu         
        730                 735                 740                     

caa ttg agg cag ctt gcc aga aga att aca gag gat cat gtg att cag     2549
Gln Leu Arg Gln Leu Ala Arg Arg Ile Thr Glu Asp His Val Ile Gln         
    745                 750                 755                         

cat ggg ctg gta gtg gat ggg acc agc cta tct ctt gca ctc agg gag     2597
His Gly Leu Val Val Asp Gly Thr Ser Leu Ser Leu Ala Leu Arg Glu         
760                 765                 770                 775         

cat gaa aaa cta ttt atg gaa gtt tgc aga aat tgt tca gct gta tta     2645
His Glu Lys Leu Phe Met Glu Val Cys Arg Asn Cys Ser Ala Val Leu         
                780                 785                 790             

tgc tgt cgt atg gct cca ctg cag aaa gca aaa gta ata aga cta ata     2693
Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Lys Val Ile Arg Leu Ile         
            795                 800                 805                 

aaa ata tca cct gag aaa cct ata aca ttg gct gtt ggt gat ggt gct     2741
Lys Ile Ser Pro Glu Lys Pro Ile Thr Leu Ala Val Gly Asp Gly Ala         
        810                 815                 820                     

aat gac gta agc atg ata caa gaa gcc cat gtt ggc ata gga atc atg     2789
Asn Asp Val Ser Met Ile Gln Glu Ala His Val Gly Ile Gly Ile Met         
    825                 830                 835                         

ggt aaa gaa gga aga cag gct gca aga aac agt gac tat gca ata gcc     2837
Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile Ala         
840                 845                 850                 855         

aga ttt aag ttc ctc tcc aaa ttg ctt ttt gtt cat ggt cat ttt tat     2885
Arg Phe Lys Phe Leu Ser Lys Leu Leu Phe Val His Gly His Phe Tyr         
                860                 865                 870             

tat att aga ata gct acc ctt gta cag tat ttt ttt tat aag aat gtg     2933
Tyr Ile Arg Ile Ala Thr Leu Val Gln Tyr Phe Phe Tyr Lys Asn Val         
            875                 880                 885                 

tgc ttt atc aca ccc cag ttt tta tat cag ttc tac tgt ttg ttt tct     2981
Cys Phe Ile Thr Pro Gln Phe Leu Tyr Gln Phe Tyr Cys Leu Phe Ser         
        890                 895                 900                     

cag caa aca ttg tat gac agc gtg tac ctg act tta tac aat att tgt     3029
Gln Gln Thr Leu Tyr Asp Ser Val Tyr Leu Thr Leu Tyr Asn Ile Cys         
    905                 910                 915                         

ttt act tcc cta cct att ctg ata tat agt ctt ttg gaa cag cat gta     3077
Phe Thr Ser Leu Pro Ile Leu Ile Tyr Ser Leu Leu Glu Gln His Val         
920                 925                 930                 935         

gac cct cat gtg tta caa aat aag ccc acc ctt tat cga gac att agt     3125
Asp Pro His Val Leu Gln Asn Lys Pro Thr Leu Tyr Arg Asp Ile Ser         
                940                 945                 950             

aaa aac cgc ctc tta agt att aaa aca ttt ctt tat tgg acc atc ctg     3173
Lys Asn Arg Leu Leu Ser Ile Lys Thr Phe Leu Tyr Trp Thr Ile Leu         
            955                 960                 965                 

ggc ttc agt cat gcc ttt att ttc ttt ttt gga tcc tat tta cta ata     3221
Gly Phe Ser His Ala Phe Ile Phe Phe Phe Gly Ser Tyr Leu Leu Ile         
        970                 975                 980                     

ggg aaa gat aca tct ctg ctt gga aat ggc cag atg ttt gga aac tgg     3269
Gly Lys Asp Thr Ser Leu Leu Gly Asn Gly Gln Met Phe Gly Asn Trp         
    985                 990                 995                         

aca  ttt ggc act ttg gtc  ttc aca gtc atg gtt  att aca gtc aca      3314
Thr  Phe Gly Thr Leu Val  Phe Thr Val Met Val  Ile Thr Val Thr          
1000                 1005                 1010                          

gta  aag atg gct ctg gaa  act cat ttt tgg act  tgg atc aac cat      3359
Val  Lys Met Ala Leu Glu  Thr His Phe Trp Thr  Trp Ile Asn His          
1015                 1020                 1025                          

ctc  gtt acc tgg gga tct  att ata ttt tat ttt  gta ttt tcc ttg      3404
Leu  Val Thr Trp Gly Ser  Ile Ile Phe Tyr Phe  Val Phe Ser Leu          
1030                 1035                 1040                          

ttt  tat gga ggg att ctc  tgg cca ttt ttg ggc  tcc cag aat atg      3449
Phe  Tyr Gly Gly Ile Leu  Trp Pro Phe Leu Gly  Ser Gln Asn Met          
1045                 1050                 1055                          

tat  ttt gtg ttt att cag  ctc ctg tca agt ggt  tct gct tgg ttt      3494
Tyr  Phe Val Phe Ile Gln  Leu Leu Ser Ser Gly  Ser Ala Trp Phe          
1060                 1065                 1070                          

gcc  ata atc ctc atg gtt  gtt aca tgt cta ttt  ctt gat atc ata      3539
Ala  Ile Ile Leu Met Val  Val Thr Cys Leu Phe  Leu Asp Ile Ile          
1075                 1080                 1085                          

aag  aag gtc ttt gac cga  cac ctc cac cct aca  agt act gaa aag      3584
Lys  Lys Val Phe Asp Arg  His Leu His Pro Thr  Ser Thr Glu Lys          
1090                 1095                 1100                          

gca  cag ctt act gaa aca  aat gca ggt atc aag  tgc ttg gac tcc      3629
Ala  Gln Leu Thr Glu Thr  Asn Ala Gly Ile Lys  Cys Leu Asp Ser          
1105                 1110                 1115                          

atg  tgc tgt ttc ccg gaa  gga gaa gca gcg tgt  gca tct gtt gga      3674
Met  Cys Cys Phe Pro Glu  Gly Glu Ala Ala Cys  Ala Ser Val Gly          
1120                 1125                 1130                          

aga  atg ctg gaa cga gtt  ata gga aga tgt agt  cca acc cac atc      3719
Arg  Met Leu Glu Arg Val  Ile Gly Arg Cys Ser  Pro Thr His Ile          
1135                 1140                 1145                          

agc  aga tca tgg agt gca  tcg gat cct ttc tat  acc aac gac agg      3764
Ser  Arg Ser Trp Ser Ala  Ser Asp Pro Phe Tyr  Thr Asn Asp Arg          
1150                 1155                 1160                          

agc  atc ttg act ctc tcc  aca atg gac tca tct  act tgt taa          3806
Ser  Ile Leu Thr Leu Ser  Thr Met Asp Ser Ser  Thr Cys                  
1165                 1170                 1175                          

aggggcagta gtactttgtg ggagccagtt cacctccttt cctaaaattc agtgtgatca   3866

ccctgttaat ggccacacta gctctgaaat taatttccaa aatctttgta gtagttcata   3926

cccactcaga gttataatgg caaacaaaca gaaagcatta gtacaagccc ctcccaacac   3986

ccttaatttg aatctgaaca tgttaaaatt tgagaataaa gagacatttt tcatctcttt   4046

gtctggtttg tcccttgtgc ttatgggact cctaatggca tttcagtctg ttgctgaggc   4106

cattatattt taatataaat gtagaaaaaa gagagaaatc ttagtaaaga gtatttttta   4166

gtattagctt gattattgac tcttctattt aaatctgctt ctgtaaatta tgctgaaagt   4226

ttgccttgag aactctattt ttttattaga gttatattta aagcttttca tgggaaaagt   4286

taatgtgaat actgaggaat tttggtccct cagtgacctg tgttgttaat tcattaatgc   4346

attctgagtt cacagagcaa attaggagaa tcatttccaa ccattattta ctgcagtatg   4406

gggagtaaat ttataccaat tcctctaact gtactgtaac acagcctgta aagttagcca   4466

tataaatgca agggtatatc atatatacaa atcaggaatc aggtccgttc accgaacttc   4526

aaattgatgt ttactaatat ttttgtgaca gagtataaag accctatagt gggtaaatta   4586

gatactatta gcatattatt aatttaatgt ctttatcatt ggatcttttg catgctttaa   4646

tctggttaac atatttaaat ttgctttttt tctctttacc tgaaggctct gtgtatagta   4706

tttcatgaca tcgttgtaca gtttaactat atcaataaaa agtttggaca gtatttaaat   4766

attgcaaata tgtttaatta tacaaatcag aatagtatgg gtaattaaat gaatacaaaa   4826

agaagagcct ctttctgcag ccgacttaga catgctcttc cctttctata agctagattt   4886

tagaataaag ggtttcagtt aataatctta ttttcaggtt atgtcatcta acttatagca   4946

aactaccaca atacagtgag ttctgccagt gtcccagtac aaggcatatt tcaggtgtgg   5006

ctgtggaatg taaaaatgct caacttgtat caggtaatgt tagcaataaa ttaaatgcta   5066

agaatgatta atcgggtaca tgttactgta attaactcat tgcacttcaa agacctaact   5126

tccatcctgc aatgtcagtc aagtagttca gtatagtcat tagtttttgt tttattgaaa   5186

agtaatgttg tcttaagatt tagaagtgat tattagcttg agaactatta cccagctcta   5246

agcaaataat gattgtatac atattaagat aatggttaaa tgcggtttta ccaagttttc   5306

ccttgaaaat gtaattcctt tatggagatt tattgtgcag ccctaagctt ccttcccatt   5366

tcatgaatat aaggcttcta gaattggact ggcaggggaa agaatggtag agacagaaat   5426

taagacttta tccttgtttg cttgtaaact attattttct tgctaatgta acatttgtct   5486

gttccagtga tgtaaggata ttaagttatt aagctaaata ttaattttca aaaatagtcc   5546

ttctttaact tagatatttc atagctggat ttaggaagat ctgttattct ggaagtacta   5606

aaaagaataa tacaacgtac aatgtctgca ttcactaatt catgttccag aagaggaaat   5666

aatgaagata tactcagtag agtactaggt gggaggatat ggaaatttgc tcataaaatc   5726

tcttataaaa cgtgcatata acaaaatgac acccagtagg cctgcattac atttacatga   5786

ccgtgtttat ttgccatcaa ataaactgag tactgacacc agacaaagac tccaaagtca   5846

taaaatagcc tatgaccaac tgcagcaaga caggaggtca gctcgcctat aatggtgctt   5906

aaagtgtgat tgatgtaatt ttctgtactc accatttgaa gttagttaag gagaacttta   5966

tttttttaaa aaaagtaaat ggcaaccact agtgtgctca tcctgaactg ttactccaaa   6026

tccactccgt ttttaaagca aaattatctt gtgattttaa gaaaagagtt ttctatttat   6086

ttaagaaagt aacaatgcag tctgcaagct ttcagtagtt ttctagtgct atattcatcc   6146

tgtaaaactc ttactacgta accagtaatc acaaggaaag tgtccccttt gcatatttct   6206

ttaaaattct ttctttggaa agtatgatgt tgataattaa cttaccctta tctgccaaaa   6266

ccagagcaaa atgctaaata cgttattgct aatcagtggt ctcaaatcga tttgcctccc   6326

tttgcctcgt ctgagggctg taagcctgaa gatagtggca agcaccaagt cagtttccaa   6386

aattgcccct cagctgcttt aagtgactca gcaccctgcc tcagcttcag caggcgtagg   6446

ctcaccctgg gcggagcaaa gtatgggcca gggagaacta cagctacgaa gacctgctgt   6506

cgagttgaga aaaggggaga atttatggtc tgaattttct aactgtcctc tttcttgggt   6566

ctaaagctca taatacacaa aggcttccag acctgagcca cacccaggcc ctatcctgaa   6626

caggagacta aacagaggca aatcaaccct aggaaatact tgcattctgc cctacggtta   6686

gtaccaggac tgaggtcatt tctactggaa aagattgtga gattgaactt atctgatcgc   6746

ttgagactcc taataggcag gagtcaaggc cactagaaaa ttgacagtta agagccaaaa   6806

gtttttaaaa tatgctactc tgaaaaatct cgtgaaggct gtaggaaaag ggagaatctt   6866

ccatgttggt gtttttcctg taaagatcag tttggggtat gatataagca ggtattaata   6926

aaaataacac accaaagagt tacgtaaaac atgttttatt aattttggtc cccacgtaca   6986

gacattttat ttctattttg aaatgagtta tctattttca taaaagtaaa acactattaa   7046

agtgctgttt tatgtgaaat aacttgaatg ttgttcctat aaaaaataga tcataactca   7106

tgatatgttt gtaatcatgg taatttagat ttttatgagg aatgagtatc tggaaatatt   7166

gtagcaatac ttggtttaaa attttggacc tgagacactg tggctgtcta atgtaatcct   7226

ttaaaaattc tctgcattgt cagtaaatgt agtatattat tgtacagcta ctcataattt   7286

tttaaagttt atgaagttat atttatcaaa taaaaacttt cctatataaa aaaaaaaaaa   7346

a                                                                   7347


<210>  2

<211>  1177

<212>  PRT

<213>  Homo sapiens



<400>  2

Met Trp Arg Trp Ile Arg Gln Gln Leu Gly Phe Asp Pro Pro His Gln 
1               5                   10                  15      


Ser Asp Thr Arg Thr Ile Tyr Val Ala Asn Arg Phe Pro Gln Asn Gly 
            20                  25                  30          


Leu Tyr Thr Pro Gln Lys Phe Ile Asp Asn Arg Ile Ile Ser Ser Lys 
        35                  40                  45              


Tyr Thr Val Trp Asn Phe Val Pro Lys Asn Leu Phe Glu Gln Phe Arg 
    50                  55                  60                  


Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu Val Gln Leu Met 
65                  70                  75                  80  


Ile Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu Pro Leu Phe Phe 
                85                  90                  95      


Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu Asp Trp Leu Arg 
            100                 105                 110         


His Asn Ser Asp Asn Glu Val Asn Gly Ala Pro Val Tyr Val Val Arg 
        115                 120                 125             


Ser Gly Gly Leu Val Lys Thr Arg Ser Lys Asn Ile Arg Val Gly Asp 
    130                 135                 140                 


Ile Val Arg Ile Ala Lys Asp Glu Ile Phe Pro Ala Asp Leu Val Leu 
145                 150                 155                 160 


Leu Ser Ser Asp Arg Leu Asp Gly Ser Cys His Val Thr Thr Ala Ser 
                165                 170                 175     


Leu Asp Gly Glu Thr Asn Leu Lys Thr His Val Ala Val Pro Glu Thr 
            180                 185                 190         


Ala Leu Leu Gln Thr Val Ala Asn Leu Asp Thr Leu Val Ala Val Ile 
        195                 200                 205             


Glu Cys Gln Gln Pro Glu Ala Asp Leu Tyr Arg Phe Met Gly Arg Met 
    210                 215                 220                 


Ile Ile Thr Gln Gln Met Glu Glu Ile Val Arg Pro Leu Gly Pro Glu 
225                 230                 235                 240 


Ser Leu Leu Leu Arg Gly Ala Arg Leu Lys Asn Thr Lys Glu Ile Phe 
                245                 250                 255     


Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys Met Ala Leu Asn Tyr 
            260                 265                 270         


Lys Ser Lys Ser Gln Lys Arg Ser Ala Val Gln Lys Ser Met Asn Thr 
        275                 280                 285             


Phe Leu Ile Ile Tyr Leu Val Ile Leu Ile Ser Glu Ala Val Ile Ser 
    290                 295                 300                 


Thr Ile Leu Lys Tyr Thr Trp Gln Ala Glu Glu Lys Trp Asp Glu Pro 
305                 310                 315                 320 


Trp Tyr Asn Gln Lys Thr Glu His Gln Arg Asn Ser Ser Lys Ile Leu 
                325                 330                 335     


Arg Phe Ile Ser Asp Phe Leu Ala Phe Leu Val Leu Tyr Asn Phe Ile 
            340                 345                 350         


Ile Pro Ile Ser Leu Tyr Val Thr Val Glu Met Gln Lys Phe Leu Gly 
        355                 360                 365             


Ser Phe Phe Ile Gly Trp Asp Leu Asp Leu Tyr His Glu Glu Ser Asp 
    370                 375                 380                 


Gln Lys Ala Gln Val Asn Thr Ser Asp Leu Asn Glu Glu Leu Gly Gln 
385                 390                 395                 400 


Val Glu Tyr Val Phe Thr Asp Lys Thr Gly Thr Leu Thr Glu Asn Glu 
                405                 410                 415     


Met Gln Phe Arg Glu Cys Ser Ile Asn Gly Met Lys Tyr Gln Glu Ile 
            420                 425                 430         


Asn Gly Arg Leu Val Pro Glu Gly Pro Thr Pro Asp Ser Ser Glu Gly 
        435                 440                 445             


Asn Leu Ser Tyr Leu Ser Ser Leu Ser His Leu Asn Asn Leu Ser His 
    450                 455                 460                 


Leu Thr Thr Ser Ser Ser Phe Arg Thr Ser Pro Glu Asn Glu Thr Glu 
465                 470                 475                 480 


Leu Ile Lys Glu His Asp Leu Phe Phe Lys Ala Val Ser Leu Cys His 
                485                 490                 495     


Thr Val Gln Ile Ser Asn Val Gln Thr Asp Cys Thr Gly Asp Gly Pro 
            500                 505                 510         


Trp Gln Ser Asn Leu Ala Pro Ser Gln Leu Glu Tyr Tyr Ala Ser Ser 
        515                 520                 525             


Pro Asp Glu Lys Ala Leu Val Glu Ala Ala Ala Arg Ile Gly Ile Val 
    530                 535                 540                 


Phe Ile Gly Asn Ser Glu Glu Thr Met Glu Val Lys Thr Leu Gly Lys 
545                 550                 555                 560 


Leu Glu Arg Tyr Lys Leu Leu His Ile Leu Glu Phe Asp Ser Asp Arg 
                565                 570                 575     


Arg Arg Met Ser Val Ile Val Gln Ala Pro Ser Gly Glu Lys Leu Leu 
            580                 585                 590         


Phe Ala Lys Gly Ala Glu Ser Ser Ile Leu Pro Lys Cys Ile Gly Gly 
        595                 600                 605             


Glu Ile Glu Lys Thr Arg Ile His Val Asp Glu Phe Ala Leu Lys Gly 
    610                 615                 620                 


Leu Arg Thr Leu Cys Ile Ala Tyr Arg Lys Phe Thr Ser Lys Glu Tyr 
625                 630                 635                 640 


Glu Glu Ile Asp Lys Arg Ile Phe Glu Ala Arg Thr Ala Leu Gln Gln 
                645                 650                 655     


Arg Glu Glu Lys Leu Ala Ala Val Phe Gln Phe Ile Glu Lys Asp Leu 
            660                 665                 670         


Ile Leu Leu Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Asp Lys Val 
        675                 680                 685             


Arg Glu Thr Ile Glu Ala Leu Arg Met Ala Gly Ile Lys Val Trp Val 
    690                 695                 700                 


Leu Thr Gly Asp Lys His Glu Thr Ala Val Ser Val Ser Leu Ser Cys 
705                 710                 715                 720 


Gly His Phe His Arg Thr Met Asn Ile Leu Glu Leu Ile Asn Gln Lys 
                725                 730                 735     


Ser Asp Ser Glu Cys Ala Glu Gln Leu Arg Gln Leu Ala Arg Arg Ile 
            740                 745                 750         


Thr Glu Asp His Val Ile Gln His Gly Leu Val Val Asp Gly Thr Ser 
        755                 760                 765             


Leu Ser Leu Ala Leu Arg Glu His Glu Lys Leu Phe Met Glu Val Cys 
    770                 775                 780                 


Arg Asn Cys Ser Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys 
785                 790                 795                 800 


Ala Lys Val Ile Arg Leu Ile Lys Ile Ser Pro Glu Lys Pro Ile Thr 
                805                 810                 815     


Leu Ala Val Gly Asp Gly Ala Asn Asp Val Ser Met Ile Gln Glu Ala 
            820                 825                 830         


His Val Gly Ile Gly Ile Met Gly Lys Glu Gly Arg Gln Ala Ala Arg 
        835                 840                 845             


Asn Ser Asp Tyr Ala Ile Ala Arg Phe Lys Phe Leu Ser Lys Leu Leu 
    850                 855                 860                 


Phe Val His Gly His Phe Tyr Tyr Ile Arg Ile Ala Thr Leu Val Gln 
865                 870                 875                 880 


Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Thr Pro Gln Phe Leu Tyr 
                885                 890                 895     


Gln Phe Tyr Cys Leu Phe Ser Gln Gln Thr Leu Tyr Asp Ser Val Tyr 
            900                 905                 910         


Leu Thr Leu Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ile Tyr 
        915                 920                 925             


Ser Leu Leu Glu Gln His Val Asp Pro His Val Leu Gln Asn Lys Pro 
    930                 935                 940                 


Thr Leu Tyr Arg Asp Ile Ser Lys Asn Arg Leu Leu Ser Ile Lys Thr 
945                 950                 955                 960 


Phe Leu Tyr Trp Thr Ile Leu Gly Phe Ser His Ala Phe Ile Phe Phe 
                965                 970                 975     


Phe Gly Ser Tyr Leu Leu Ile Gly Lys Asp Thr Ser Leu Leu Gly Asn 
            980                 985                 990         


Gly Gln Met Phe Gly Asn Trp Thr  Phe Gly Thr Leu Val  Phe Thr Val 
        995                 1000                 1005             


Met Val  Ile Thr Val Thr Val  Lys Met Ala Leu Glu  Thr His Phe 
    1010                 1015                 1020             


Trp Thr  Trp Ile Asn His Leu  Val Thr Trp Gly Ser  Ile Ile Phe 
    1025                 1030                 1035             


Tyr Phe  Val Phe Ser Leu Phe  Tyr Gly Gly Ile Leu  Trp Pro Phe 
    1040                 1045                 1050             


Leu Gly  Ser Gln Asn Met Tyr  Phe Val Phe Ile Gln  Leu Leu Ser 
    1055                 1060                 1065             


Ser Gly  Ser Ala Trp Phe Ala  Ile Ile Leu Met Val  Val Thr Cys 
    1070                 1075                 1080             


Leu Phe  Leu Asp Ile Ile Lys  Lys Val Phe Asp Arg  His Leu His 
    1085                 1090                 1095             


Pro Thr  Ser Thr Glu Lys Ala  Gln Leu Thr Glu Thr  Asn Ala Gly 
    1100                 1105                 1110             


Ile Lys  Cys Leu Asp Ser Met  Cys Cys Phe Pro Glu  Gly Glu Ala 
    1115                 1120                 1125             


Ala Cys  Ala Ser Val Gly Arg  Met Leu Glu Arg Val  Ile Gly Arg 
    1130                 1135                 1140             


Cys Ser  Pro Thr His Ile Ser  Arg Ser Trp Ser Ala  Ser Asp Pro 
    1145                 1150                 1155             


Phe Tyr  Thr Asn Asp Arg Ser  Ile Leu Thr Leu Ser  Thr Met Asp 
    1160                 1165                 1170             


Ser Ser  Thr Cys 
    1175         


<210>  3

<211>  1107

<212>  PRT

<213>  Oryctolagus cuniculus



<400>  3

Leu Gly Phe Asp Pro Pro His Gln Ser Asp Thr Arg Thr Ile Tyr Ile 
1               5                   10                  15      


Ala Asn Arg Phe Pro Gln Asn Gly Leu Tyr Thr Pro Gln Lys Phe Ile 
            20                  25                  30          


Asp Asn Arg Ile Ile Ser Ser Lys Tyr Thr Val Trp Asn Phe Val Pro 
        35                  40                  45              


Lys Asn Leu Phe Glu Gln Phe Arg Arg Val Ala Asn Phe Tyr Phe Leu 
    50                  55                  60                  


Ile Ile Phe Leu Val Gln Leu Met Ile Asp Thr Pro Thr Ser Pro Ile 
65                  70                  75                  80  


Thr Ser Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys 
                85                  90                  95      


Gln Gly Tyr Glu Asp Trp Leu Arg His Asn Ser Asp Asn Glu Val Asn 
            100                 105                 110         


Gly Ala Pro Val Tyr Val Val Arg Ser Gly Gly Leu Val Lys Thr Arg 
        115                 120                 125             


Ser Lys Asn Ile Arg Gly Met His Leu Val Gly Asp Ile Val Arg Ile 
    130                 135                 140                 


Ala Lys Asp Glu Ile Phe Pro Ala Asp Leu Val Leu Leu Ser Ser Asp 
145                 150                 155                 160 


Arg Leu Asp Gly Ser Cys His Val Thr Thr Ala Ser Leu Asp Gly Glu 
                165                 170                 175     


Thr Asn Leu Lys Thr His Val Ala Val Pro Glu Thr Ala Val Leu Gln 
            180                 185                 190         


Thr Val Ala Asn Leu Asp Thr Leu Val Ala Val Ile Glu Cys Gln Gln 
        195                 200                 205             


Pro Glu Ala Asp Leu Tyr Arg Phe Met Gly Arg Met Val Ile Thr Gln 
    210                 215                 220                 


Gln Met Glu Glu Ile Val Arg Pro Leu Gly Pro Glu Ser Leu Leu Leu 
225                 230                 235                 240 


Arg Gly Ala Arg Leu Lys Asn Thr Lys Glu Ile Phe Gly Val Ala Val 
                245                 250                 255     


Tyr Thr Gly Met Glu Thr Lys Met Ala Leu Asn Tyr Lys Ser Lys Ser 
            260                 265                 270         


Gln Lys Arg Ser Ala Val Glu Lys Ser Met Asn Thr Phe Leu Thr Ile 
        275                 280                 285             


Tyr Leu Ile Ile Leu Ile Ser Glu Ala Ile Ile Ser Thr Ile Leu Lys 
    290                 295                 300                 


Tyr Thr Trp Gln Ala Glu Glu Lys Trp Asp Glu Pro Trp Tyr Asn Gln 
305                 310                 315                 320 


Lys Thr Glu His Gln Arg Asn Ser Ser Lys Val Glu Tyr Val Phe Thr 
                325                 330                 335     


Asp Lys Thr Gly Thr Leu Thr Glu Asn Glu Met Gln Phe Arg Glu Cys 
            340                 345                 350         


Ser Ile His Gly Met Lys Tyr Gln Glu Ile Asn Gly Arg Leu Val Pro 
        355                 360                 365             


Glu Gly Pro Thr Pro Asp Ser Ser Glu Gly Asn Leu Ser Tyr Leu Ser 
    370                 375                 380                 


Ser Leu Ser His Val Asn Ser Leu Ser His Leu Thr Ser Ser Ser Ser 
385                 390                 395                 400 


Phe Arg Thr Ser Pro Glu Asn Asp Thr Glu Leu Ile Lys Glu His Asp 
                405                 410                 415     


Leu Phe Phe Lys Ala Val Ser Leu Cys His Thr Val Gln Ile Ser Ser 
            420                 425                 430         


Val Gln Thr Asp Gly Ile Gly Asp Gly Pro Trp Gln Ser Ser Leu Ala 
        435                 440                 445             


Pro Ser Gln Leu Glu Tyr Tyr Ala Ser Ser Pro Asp Glu Lys Ala Leu 
    450                 455                 460                 


Val Glu Ala Ala Ala Arg Ile Gly Ile Val Phe Val Gly Asn Thr Glu 
465                 470                 475                 480 


Glu Thr Met Glu Val Lys Ile Leu Gly Lys Leu Glu Arg Tyr Lys Leu 
                485                 490                 495     


Leu His Val Leu Glu Phe Asp Ser Asp Arg Arg Arg Met Ser Val Ile 
            500                 505                 510         


Val Gln Ala Pro Ser Gly Glu Arg Phe Leu Phe Ala Lys Gly Ala Glu 
        515                 520                 525             


Ser Ser Ile Leu Pro Lys Cys Ile Gly Gly Glu Ile Glu Lys Thr Arg 
    530                 535                 540                 


Ile His Val Asp Glu Phe Ala Leu Lys Gly Leu Arg Thr Leu Cys Val 
545                 550                 555                 560 


Ala Tyr Arg Gln Phe Thr Ser Lys Glu Tyr Glu Val Ile Asp Arg Arg 
                565                 570                 575     


Leu Phe Glu Ala Arg Thr Ala Leu Gln Gln Arg Glu Glu Lys Leu Ala 
            580                 585                 590         


Asp Val Phe His Tyr Ile Glu Lys Asp Leu Ile Leu Leu Gly Ala Thr 
        595                 600                 605             


Ala Val Glu Asp Arg Leu Gln Asp Lys Val Arg Glu Thr Ile Glu Ala 
    610                 615                 620                 


Leu Arg Met Ala Gly Ile Lys Val Trp Val Leu Thr Gly Asp Lys His 
625                 630                 635                 640 


Glu Thr Ala Val Ser Val Ser Leu Ser Cys Gly His Phe His Arg Thr 
                645                 650                 655     


Met Asn Ile Leu Glu Leu Thr Asn Gln Lys Ser Asp Ser Glu Cys Ala 
            660                 665                 670         


Glu Gln Leu Arg Gln Leu Ala Arg Arg Ile Thr Glu Asp His Val Ile 
        675                 680                 685             


Gln His Gly Leu Val Val Asp Gly Thr Ser Leu Ser Leu Ala Leu Arg 
    690                 695                 700                 


Glu His Glu Lys Leu Phe Met Glu Val Cys Arg Asn Cys Ser Ala Val 
705                 710                 715                 720 


Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Lys Val Ile Arg Leu 
                725                 730                 735     


Ile Lys Ile Ser Pro Glu Lys Pro Ile Thr Ile Gly Cys Trp Asp Gly 
            740                 745                 750         


Ala Asn Asp Val Ser Met Ile Gln Glu Ala His Val Gly Ile Gly Ile 
        755                 760                 765             


Met Gly Lys Glu Arg Arg Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile 
    770                 775                 780                 


Ala Arg Phe Lys Phe Leu Ser Lys Leu Leu Phe Val His Gly His Phe 
785                 790                 795                 800 


Tyr Tyr Ile Arg Ile Ala Thr Leu Val Gln Tyr Phe Phe Tyr Lys Asn 
                805                 810                 815     


Val Cys Phe Ile Thr Pro Gln Phe Leu Tyr Gln Phe Tyr Cys Leu Phe 
            820                 825                 830         


Ser Gln Gln Thr Leu Tyr Asp Ser Val Tyr Leu Thr Leu Tyr Asn Ile 
        835                 840                 845             


Cys Phe Thr Ser Leu Pro Ile Leu Ile Tyr Ser Leu Leu Glu Gln His 
    850                 855                 860                 


Ile Asp Pro His Ile Leu Gln Asn Lys Pro Thr Leu Tyr Arg Asp Ile 
865                 870                 875                 880 


Ser Lys Asn Arg Leu Leu Ser Ile Lys Thr Phe Leu Tyr Trp Thr Ile 
                885                 890                 895     


Leu Gly Phe Ser Arg Ser Phe Ile Phe Leu Phe Gly Ser Tyr Phe Leu 
            900                 905                 910         


Ile Gly Lys Asp Ala Ser Leu Leu Gly Asn Gly Gln Met Phe Gly Asn 
        915                 920                 925             


Trp Thr Phe Gly Thr Leu Val Phe Thr Val Met Val Ile Thr Val Thr 
    930                 935                 940                 


Val Lys Met Ala Leu Glu Thr His Phe Trp Thr Trp Ile Asn His Leu 
945                 950                 955                 960 


Val Thr Trp Gly Ser Ile Ile Phe Tyr Phe Val Phe Ser Leu Phe Tyr 
                965                 970                 975     


Gly Gly Ile Leu Trp Pro Phe Leu Gly Ser Gln Asn Met Tyr Phe Val 
            980                 985                 990         


Phe Ile Gln Leu Val Ser Ser Gly  Ser Ala Trp Phe Ala  Ile Ile Leu 
        995                 1000                 1005             


Met Val  Val Thr Cys Leu Phe  Leu Asp Val Met Lys  Lys Val Phe 
    1010                 1015                 1020             


Asp Arg  Gln Leu His Pro Thr  Ser Thr Glu Lys Ala  Gln Leu Thr 
    1025                 1030                 1035             


Glu Thr  Asn Ser Ser Ile Lys  Cys Val Asp Ser Leu  Cys Cys Phe 
    1040                 1045                 1050             


Pro Glu  Gly Glu Thr Thr Cys  Thr Ser Val Arg Arg  Met Leu Glu 
    1055                 1060                 1065             


Arg Val  Ile Gly Arg Cys Ser  Pro Thr His Ile Ser  Arg Ser Trp 
    1070                 1075                 1080             


Ser Ala  Ser Asp Pro Phe Tyr  Thr Asn Asp Arg Ser  Ile Leu Thr 
    1085                 1090                 1095             


Leu Ser  Thr Met Asp Ser Ser  Thr Cys 
    1100                 1105         


<210>  4

<211>  672

<212>  PRT

<213>  Homo sapiens



<400>  4

Asp Cys Thr Gly Asp Gly Pro Trp Gln Ser Asn Leu Ala Pro Ser Gln 
1               5                   10                  15      


Leu Glu Tyr Tyr Ala Ser Ser Pro Asp Glu Lys Ala Leu Val Glu Ala 
            20                  25                  30          


Ala Ala Arg Ile Gly Ile Val Phe Ile Gly Asn Ser Glu Glu Thr Met 
        35                  40                  45              


Glu Val Lys Thr Leu Gly Lys Leu Glu Arg Tyr Lys Leu Leu His Ile 
    50                  55                  60                  


Leu Glu Phe Asp Ser Asp Arg Arg Arg Met Ser Val Ile Val Gln Ala 
65                  70                  75                  80  


Pro Ser Gly Glu Lys Leu Leu Phe Ala Lys Gly Ala Glu Ser Ser Ile 
                85                  90                  95      


Leu Pro Lys Cys Ile Gly Gly Glu Ile Glu Lys Thr Arg Ile His Val 
            100                 105                 110         


Asp Glu Phe Ala Leu Lys Gly Leu Arg Thr Leu Cys Ile Ala Tyr Arg 
        115                 120                 125             


Lys Phe Thr Ser Lys Glu Tyr Glu Glu Ile Asp Lys Arg Ile Phe Glu 
    130                 135                 140                 


Ala Arg Thr Ala Leu Gln Gln Arg Glu Glu Lys Leu Ala Ala Val Phe 
145                 150                 155                 160 


Gln Phe Ile Glu Lys Asp Leu Ile Leu Leu Gly Ala Thr Ala Val Glu 
                165                 170                 175     


Asp Arg Leu Gln Asp Lys Val Arg Glu Thr Ile Glu Ala Leu Arg Met 
            180                 185                 190         


Ala Gly Ile Lys Val Trp Val Leu Thr Gly Asp Lys His Glu Thr Ala 
        195                 200                 205             


Val Ser Val Ser Leu Ser Cys Gly His Phe His Arg Thr Met Asn Ile 
    210                 215                 220                 


Leu Glu Leu Ile Asn Gln Lys Ser Asp Ser Glu Cys Ala Glu Gln Leu 
225                 230                 235                 240 


Arg Gln Leu Ala Arg Arg Ile Thr Glu Asp His Val Ile Gln His Gly 
                245                 250                 255     


Leu Val Val Asp Gly Thr Ser Leu Ser Leu Ala Leu Arg Glu His Glu 
            260                 265                 270         


Lys Leu Phe Met Glu Val Cys Arg Asn Cys Ser Ala Val Leu Cys Cys 
        275                 280                 285             


Arg Met Ala Pro Leu Gln Lys Ala Lys Val Ile Arg Leu Ile Lys Ile 
    290                 295                 300                 


Ser Pro Glu Lys Pro Ile Thr Leu Ala Val Gly Asp Gly Ala Asn Asp 
305                 310                 315                 320 


Val Ser Met Ile Gln Glu Ala His Val Gly Ile Gly Ile Met Gly Lys 
                325                 330                 335     


Glu Gly Arg Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile Ala Arg Phe 
            340                 345                 350         


Lys Phe Leu Ser Lys Leu Leu Phe Val His Gly His Phe Tyr Tyr Ile 
        355                 360                 365             


Arg Ile Ala Thr Leu Val Gln Tyr Phe Phe Tyr Lys Asn Val Cys Phe 
    370                 375                 380                 


Ile Thr Pro Gln Phe Leu Tyr Gln Phe Tyr Cys Leu Phe Ser Gln Gln 
385                 390                 395                 400 


Thr Leu Tyr Asp Ser Val Tyr Leu Thr Leu Tyr Asn Ile Cys Phe Thr 
                405                 410                 415     


Ser Leu Pro Ile Leu Ile Tyr Ser Leu Leu Glu Gln His Val Asp Pro 
            420                 425                 430         


His Val Leu Gln Asn Lys Pro Thr Leu Tyr Arg Asp Ile Ser Lys Asn 
        435                 440                 445             


Arg Leu Leu Ser Ile Lys Thr Phe Leu Tyr Trp Thr Ile Leu Gly Phe 
    450                 455                 460                 


Ser His Ala Phe Ile Phe Phe Phe Gly Ser Tyr Leu Leu Ile Gly Lys 
465                 470                 475                 480 


Asp Thr Ser Leu Leu Gly Asn Gly Gln Met Phe Gly Asn Trp Thr Phe 
                485                 490                 495     


Gly Thr Leu Val Phe Thr Val Met Val Ile Thr Val Thr Val Lys Met 
            500                 505                 510         


Ala Leu Glu Thr His Phe Trp Thr Trp Ile Asn His Leu Val Thr Trp 
        515                 520                 525             


Gly Ser Ile Ile Phe Tyr Phe Val Phe Ser Leu Phe Tyr Gly Gly Ile 
    530                 535                 540                 


Leu Trp Pro Phe Leu Gly Ser Gln Asn Met Tyr Phe Val Phe Ile Gln 
545                 550                 555                 560 


Leu Leu Ser Ser Gly Ser Ala Trp Phe Ala Ile Ile Leu Met Val Val 
                565                 570                 575     


Thr Cys Leu Phe Leu Asp Ile Ile Lys Lys Val Phe Asp Arg His Leu 
            580                 585                 590         


His Pro Thr Ser Thr Glu Lys Ala Gln Leu Thr Glu Thr Asn Ala Gly 
        595                 600                 605             


Ile Lys Cys Leu Asp Ser Met Cys Cys Phe Pro Glu Gly Glu Ala Ala 
    610                 615                 620                 


Cys Ala Ser Val Gly Arg Met Leu Glu Arg Val Ile Gly Arg Cys Ser 
625                 630                 635                 640 


Pro Thr His Ile Ser Arg Ser Trp Ser Ala Ser Asp Pro Phe Tyr Thr 
                645                 650                 655     


Asn Asp Arg Ser Ile Leu Thr Leu Ser Thr Met Asp Ser Ser Thr Cys 
            660                 665                 670         


<210>  5

<211>  12

<212>  PRT

<213>  Homo sapiens



<400>  5

Ser Ala Ser Asp Pro Phe Tyr Thr Asn Asp Arg Ser 
1               5                   10          


